The items are in alphabetical order.
| Item | Price | Location | Description |
| Antidote | 100 | PokeMart | Cures Poison |
| Awakening | 250 | PokeMart | Cures Sleep |
| Bicycle | 1 Million | Cerulean City-Bike Shop | Allows you to go faster |
| Bike Voucher | ----- | Vermilion City-Pokemon Fan Club | Used to buy a bike |
| Burn Heal | 250 | PokeMart | Heals Burns |
| Calcium | 9,800 | Celadon City-Department Store | Boosts Special rating |
| Carbos | 9,800 | Celadon City-Department Store | Boosts Speed rating |
| Card Key | ----- | Saffron City-Silph Company Building | Opens Silph Co. doors |
| Coin | 1,000 (for 50) | Celadon City-Game Corner | Used to play slot machines |
| Coin Case | ----- | Celadon City-Resturant | Holds coins |
| Dire Hit | 650 | Celadon City-Department Store | Boost's attack effectiveness |
| Dome Fossil | ----- | Mt. Moon | Used to clone new Pokemon |
| Elixer | ----- | Various Areas | Gives 10 PP to all abilities |
| Escape Rope | 550 | PokeMart | Used to escape current area |
| Ether | ----- | Various Areas | Gives 10 PP to one ability |
| Exp. All | ----- | Route 15 | Used to share exp. points |
| Fire Stone | 2,100 | Celadon City-Department Store | Triggers evolution |
| Fresh Water | 200 | Celadon City-Department Store | Quenches thirst, restores 50 HP |
| Full Heal | 600 | PokeMart | Cures any condition |
| Full Restore | 3,000 | PokeMart | Cures, restores all HP |
| Gold Teeth | ----- | Fuschia City-Safari Zone | Helps Warden speak |
| Good Rod | ----- | Fuschia City | Used to fish for Pokemon |
| Great Ball | 600 | PokeMart | Used to catch Pokemon |
| Guard Spec. | 700 | Celadon City-Department Store | Disables Special Attacks |
| Helix Fossil | ----- | Mt. Moon | Used to clone new Pokemon |
| HP Up | ----- | Various Areas | Boosts HP meter by one point |
| Hyper Potion | 1,500 | PokeMart | Restores 200 HP |
| Ice Heal | 250 | PokeMart | Thaws frozed Pokemon |
| Iron | 9,800 | Celadon City-Department Store | Boosts Defense rating |
| Item Finder | ----- | Route 11 | Exposes hidden items |
| Leaf Stone | 2,100 | Celadon City-Department Store | Triggers evolution |
| Lemonade | 350 | Celadon City-Department Store | Quenches thirst, restores 80 HP |
| Lift Key | ----- | Celadon City-Game Corner | Activates elevator |
| Master Ball | ----- | Saffron City-Silph Co. Building | Used to catch Pokemon |
| Max Elixer | ----- | Various Areas | Restores all PP |
| Max Ether | ----- | Various Areas | Restores all PP to one ability |
| Max Potion | 2,500 | PokeMart | Restores all HP |
| Max Repel | 700 | PokeMart | Prevents random attacks |
| Max Revive | ----- | Various Areas | Revives, restores all HP |
| Moon Stone | ----- | Various Areas | Triggers evolution |
| Nugget | ----- | Various Areas | Can be sold for money (5,000) |
| Oak's Parcel | ----- | Viridian City-PokeMart | Belongs to Prof. Oak |
| Old Amber | ----- | Pewter City-Museum | Used to clone new Pokemon |
| Old Rod | ----- | Vermillion City | Used to fish for Pokemon |
| Paralyze Heal | 200 | PokeMart | Cures Paoalyze |
| PokeBall | 200 | PokeMart | Used to catch Pokemon |
| PokeDoll | 1,000 | Celadon City | Distracts opponent |
| PokeFlute | ----- | Lavender Town-Pokemon Tower | Wakes sleeping Pokemon |
| PokeDex | ----- | Pallet Town | Used to store Pokemon data |
| Potion | 300 | PokeMart | Restores 20 HP |
| PP Up | ----- | Various Areas | Boosts PP meter by one point |
| Protien | 9,800 | Celadon City-Department Store | Poosts Attack rating |
| Rare Candy | ----- | Various Areas | Boosts experience level |
| Repel | 350 | PokeMart | Prevents random Attacks |
| Revive | 1,500 | PokeMart | Revives faint Pokemon |
| S.S. Ticket | ----- | Sea Cottage | Used to board S.S. Anne |
| Safari Ball | ----- | Fuschia City-Sarafi Zone | Used in Safari Zone |
| Secret Key | ----- | Cinnabar Island-Pokemon Reasearch Center | Opens Cinnibar Island Gym |
| Silph Scope | ----- | Celadon City-Game Corner | Used to identify Ghosts |
| Soda Pop | 300 | Celadon City-Department Store | Quenches thirst, restores 60 HP |
| Super Potion | 700 | PokeMart | Restores 50 HP |
| Super Repel | 500 | PokeMart | Prevents random Attacks |
| Super Rod | ----- | Route 12 | Used to fish for Pokemon |
| Thunder Stone | 2,100 | Celadon City-Department Store | Triggers evolution |
| Town Map | ----- | Pallet Town | Map of the entire game |
| Ultra Ball | 1,200 | PokeMart | Used to catch Pokemon |
| Water Stone | 2,100 | Celadon City-Department Store | Triggers evolution |
| X Accuracy | 950 | Celadon City-Department Store | Boosts Accuracy temporarily |
| X Attack | 500 | Celadon City-Department Store | Boosts Attack temporarily |
| X Defend | 550 | Celadon City-Department Store | Boosts Defense temporarily |
| X Special | 350 | Celadon City-Department Store | Boosts Special temporarily |
| X Speed | 350 | Celadon City-Department Store | Boosts Speed temporarily |